Description

3-o-(2'E,4'Z-Decadienoyl)Ingenol CAS NO 84680-59-1 is a semi-synthetic ingenol derivative, a compound of significant interest in advanced pharmaceutical research and development. Its value lies in its role as a key intermediate or active pharmaceutical ingredient (API) for investigating novel therapeutic pathways. This high-purity compound is primarily needed by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery, particularly for oncology and dermatology applications.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or reference standard in the synthesis and study of novel drug candidates, especially in oncology.
• API Synthesis: Used as a building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) targeting specific biological mechanisms.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicity profiles of new chemical entities.
• Dermatological Agent Development: Investigated for potential applications in topical treatments due to the pharmacological profile of ingenol derivatives.
• Biochemical Tool Compound: Utilized in cell biology and pharmacology research to probe specific enzyme interactions or signaling pathways.
• Reference Standard: Acts as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in laboratories.

Basic Information

Product Name	3-o-(2'E,4'Z-Decadienoyl)Ingenol
CAS No.	84680-59-1
Molecular Formula	C32H44O6
Molecular Weight	524.70 g/mol
Synonyms	Ingenol 3-(2'E,4'Z-decadienoate); Ingenol 3-angelate (related compound); 3-O-[(2E,4Z)-2,4-Decadienoyl]ingenol; (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl (2E,4Z)-2,4-decadienoate; PEP005 derivative; Ingenol ester
EINECS	Contact for details

Quality Control

Our 3-o-(2'E,4'Z-Decadienoyl)Ingenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to relevant cGMP guidelines for the production of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.