Description

2,5-Difluoropyridine is a versatile fluorinated heterocyclic building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the pyridine ring, which allows for precise modulation of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoropyridine moiety enhances biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, such as semiconductors and liquid crystals.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other fluorination-related chemical transformations.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of complex, fluorinated target molecules under cGMP conditions where required.

Basic Information

Product Name	2,5-Difluoropyridine
CAS No.	84476-99-3
Molecular Formula	C5H3F2N
Molecular Weight	115.08 g/mol
Synonyms	2,5-Difluoropyridine; Pyridine, 2,5-difluoro-; 2,5-Difluoro-pyridine; 2,5-Difluoropyridin; 2,5-Difluoropyridine (DFP); 2,5-DiFluoropyridine; 2,5-Difluoropyridine, 97+%
EINECS	Contact for details

Quality Control

Our 2,5-Difluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its nature as a fluoride/strong alkali and highly volatile compound, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed to prevent moisture ingress and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.