Description

1-(5-Isoquinolinesulfonyl)Piperazine, Dihydrochloride is a high-purity, dihydrochloride salt derivative of a key isoquinoline-sulfonamide compound, primarily utilized as a potent and selective biochemical tool in life science research. Its core value lies in its role as a cell-permeable inhibitor of specific protein kinases, enabling the study of intracellular signaling pathways. This product is essential for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on enzymology, cell biology, and early-stage drug discovery programs.

Application

• Biochemical Research: Serves as a selective inhibitor for studying Rho-associated protein kinase (ROCK) and other related kinase signaling pathways in vitro.
• Pharmaceutical Development: Used as a reference standard and a key intermediate or pharmacophore in the synthesis and screening of novel therapeutic agents targeting kinase-related diseases.
• Cell Biology Studies: Employed to investigate the role of specific kinases in cellular processes such as cytoskeleton reorganization, cell adhesion, migration, and apoptosis.
• Enzymology Assays: Acts as a critical tool compound in high-throughput screening (HTS) and enzymatic activity assays to identify and characterize new inhibitors.
• Neuroscience Research: Applied in studies exploring kinase functions in neuronal growth, differentiation, and neurodegenerative conditions.
• Cardiovascular Research: Utilized in models studying vascular smooth muscle contraction, endothelial function, and hypertension.

Basic Information

Item	Detail
Product Name	1-(5-Isoquinolinesulfonyl)Piperazine, Dihydrochloride
CAS No.	84468-24-6
Molecular Formula	C13H16Cl2N4O2S
Molecular Weight	363.26 g/mol
Synonyms	1-(5-Isoquinolinesulfonyl)piperazine dihydrochloride; 1-(Isoquinolin-5-ylsulfonyl)piperazine dihydrochloride; 5-(Piperazine-1-sulfonyl)isoquinoline dihydrochloride; H-1152 dihydrochloride; (5-Isoquinolinesulfonyl)piperazine dihydrochloride; HA-1100 dihydrochloride; HA 1100 dihydrochloride; ROCK Inhibitor H-1152 2HCl
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Isoquinolinesulfonyl)Piperazine, Dihydrochloride is manufactured and tested under strict quality management systems to ensure consistency and reliability for research applications. Our standard grade meets high-purity specifications suitable for biochemical use, with comprehensive testing including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. The product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.