Description

Isoquinoline-5-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of isoquinoline, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile sulfonylation reagent, enabling the introduction of the isoquinoline-5-sulfonyl moiety to create novel compounds with targeted properties. This intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to synthesize potential active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides by acting as a sulfonylation agent for bioactive molecules.
• Material Science: Employed in the creation of specialty polymers, dyes, and photoactive materials where the isoquinoline scaffold imparts specific electronic or optical properties.
• Bioconjugation & Probe Synthesis: Useful for labeling biomolecules (proteins, peptides) or creating fluorescent probes and affinity tags for biochemical assays.
• Chemical Library Synthesis: A valuable reagent for combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological evaluation.
• Academic & Industrial R&D: Fundamental reagent in organic synthesis research for constructing complex heterocyclic systems and studying reaction mechanisms.

Basic Information

Product Name	Isoquinoline-5-Sulfonyl Chloride
CAS No.	84468-15-5
Molecular Formula	C9H6ClNO2S
Molecular Weight	227.67 g/mol
Synonyms	5-Isoquinolinesulfonyl chloride; Isoquinoline-5-sulfonyl chloride; 5-Chlorosulfonylisoquinoline; 1-Azanaphthalene-5-sulfonyl chloride; 5-(Chlorosulfonyl)isoquinoline; Isoquinolin-5-ylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our Isoquinoline-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.