Description

(6Ar,10Ar)-9-Carboxy-6A,7,8,10A-Tetrahydro-6,6-Dimethyl-3-Pentyl-6H-Dibenzo[B,D]Pyran-1-Yl-D-Glucopyranosiduronic Acid CAS NO 84376-63-6 is a high-purity cannabinoid metabolite reference standard, specifically the glucuronide conjugate of 11-nor-9-carboxy-δ⁹-tetrahydrocannabinol (THC-COOH). This compound is essential for precise analytical quantification and method validation in forensic and clinical toxicology. It serves as a critical calibrant and control material for laboratories requiring accurate detection and measurement of THC metabolites in biological matrices.

Application

• Forensic Toxicology Reference Standard: Primary calibrant for the quantification of THC-COOH-glucuronide in urine, blood, and oral fluid samples in workplace drug testing and legal cases.
• Clinical Research & Pharmacokinetic Studies: Used to study the metabolism, distribution, and excretion of cannabinoids in human subjects.
• Method Development & Validation: Essential for developing and validating LC-MS/MS, GC-MS, and HPLC analytical methods in compliance with guidelines from SAMHSA, ISO/IEC 17025, or other accrediting bodies.
• Quality Control in Diagnostic Laboratories: Serves as a system suitability check and internal quality control sample to ensure the accuracy and precision of routine testing.
• Manufacturing of Certified Reference Materials (CRMs): Used as a starting material for the production of certified calibrators and controls for diagnostic kits.
• Doping Control in Sports: Applied in WADA-accredited laboratories for the detection of cannabinoid use in athletes.

Basic Information

Product Name	(6Ar,10Ar)-9-Carboxy-6A,7,8,10A-Tetrahydro-6,6-Dimethyl-3-Pentyl-6H-Dibenzo[B,D]Pyran-1-Yl-D-Glucopyranosiduronic Acid
CAS No.	84376-63-6
Molecular Formula	C28H38O10
Molecular Weight	534.60 g/mol
Synonyms	THC-COOH Glucuronide; 11-Nor-9-carboxy-δ⁹-tetrahydrocannabinol glucuronide; δ⁹-THC-COOH O-glucuronide; 11-Nor-δ⁹-THC-9-COOH β-D-Glucuronide; Cannabinoid Metabolite 1 (CM1); THC Metabolite Glucuronide; 84376-63-6; 1-O-(11-Nor-9-carboxy-δ⁹-tetrahydrocannabinol)-β-D-glucopyranuronic acid
EINECS	Contact for details

Quality Control

This high-purity reference material is manufactured under strict quality management systems. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) are provided, detailing batch-specific purity, chromatographic data, and storage recommendations. Our quality commitment ensures reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference retention time
Identification (MS)	Conforms to reference mass spectrum
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in methanol, acetonitrile; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.