Description

D-Glucosamine-1-13C Hydrochloride is a stable isotope-labeled derivative of glucosamine, a fundamental amino sugar and a key precursor in the biosynthesis of glycosylated proteins and lipids. This compound is essential for research requiring precise metabolic tracing and quantification in biochemical and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) focused on metabolic pathway analysis, drug metabolism studies, and the development of analytical standards.

Application

• Isotopic Tracer in Metabolic Research: Used to study the biosynthesis and turnover of glycosaminoglycans (GAGs) like hyaluronic acid and chondroitin sulfate in cartilage and connective tissue.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS assays for the accurate quantification of glucosamine and its metabolites in biological matrices.
• Biochemical Pathway Analysis: Enables the elucidation of the hexosamine biosynthesis pathway and its role in cellular signaling, insulin resistance, and diabetic complications.
• Analytical Reference Standard: Provides a certified reference material for quality control and method validation in pharmaceutical analysis and nutraceutical testing.
• Nutritional Science Research: Investigates the absorption, distribution, and utilization of glucosamine supplements in vivo.
• Glycobiology Studies: Aids in researching N-linked and O-linked glycosylation processes of proteins.

Basic Information

Product Name	D-Glucosamine-1-13C Hydrochloride
CAS No.	84247-63-2
Molecular Formula	C13C5H12ClNO5
Molecular Weight	216.61 g/mol (for 13C1 isotopologue)
Synonyms	(2R,3R,4R,5S)-3-Amino-6-(hydroxymethyl)-5-13C-tetrahydro-2H-pyran-2,4-diol hydrochloride; 2-Amino-2-deoxy-13C1-D-glucose hydrochloride; Glucosamine-1-13C HCl; Chitosamine-1-13C hydrochloride; D-Glucosamine-1-13C HCl; (3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol-1-13C hydrochloride
EINECS	Contact for details

Quality Control

Our D-Glucosamine-1-13C Hydrochloride is manufactured under controlled conditions to ensure high isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity by HPLC, and results from identity confirmation tests (IR, NMR). We adhere to stringent internal quality standards to ensure batch-to-batch consistency and reliability for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% at C-1 position
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	+70.0° to +73.0° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.