Description

Talopeptin is a potent and specific inhibitor of the metalloprotease thermolysin, derived from the culture filtrate of *Streptomyces mozunensis*. This compound is a critical research tool for studying enzymatic mechanisms and for the development of novel therapeutic agents targeting similar proteases. It is primarily utilized by pharmaceutical researchers, biochemists, and academic institutions engaged in protease inhibitor discovery, enzymology studies, and drug development pipelines.

Application

• Protease Inhibition Research: A standard inhibitor for studying the catalytic activity, substrate specificity, and inhibition kinetics of the bacterial metalloendopeptidase thermolysin.
• Enzymology & Biochemical Assays: Used as a control or reference compound in high-throughput screening (HTS) assays to identify and characterize new thermolysin-like protease inhibitors.
• Pharmaceutical Development: Serves as a lead compound or pharmacophore model in the design of inhibitors for mammalian metalloproteases, which are implicated in various diseases.
• Structural Biology Studies: Employed in X-ray crystallography and NMR studies to elucidate enzyme-inhibitor complex structures and understand binding interactions.
• Microbial Biochemistry: Used in research investigating the role of bacterial proteases in pathogenesis and as potential targets for anti-infective agents.

Basic Information

Product Name	Talopeptin
CAS No.	84235-60-9
Molecular Formula	C₁₉H₃₃N₅O₇
Molecular Weight	467.50 g/mol
Synonyms	Talopeptin; Talopeptine; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid; Thermolysin Inhibitor; Streptomyces-derived thermolysin inhibitor; NSC 326330
EINECS	Contact for details

Quality Control

Our Talopeptin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by HPLC, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) providing batch-specific data is available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Inhibits thermolysin at IC₅₀ as per reference

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.