Description

Hymenialdisine Methanoate is a synthetic derivative of the marine natural product hymenialdisine, designed for enhanced stability and research utility. This compound serves as a potent and selective inhibitor of key protein kinases, including glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinases (CDKs), making it a critical tool for probing intracellular signaling pathways. It is primarily utilized by researchers in pharmaceutical R&D and academic institutions focused on oncology, neurodegenerative diseases, and cell cycle regulation. Its defined structure and biological activity provide a valuable scaffold for mechanistic studies and drug discovery programs.

Application

• Biochemical Research: Used as a selective kinase inhibitor to study signal transduction pathways involving GSK-3β, CDK1, CDK2, and CDK5.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery of novel therapeutics for cancer and Alzheimer's disease.
• Cell Biology Studies: Applied in vitro to investigate the effects of kinase inhibition on cell proliferation, apoptosis, and neuronal function.
• Enzyme Assay Development: Utilized as a control inhibitor in high-throughput screening (HTS) assays to identify new kinase modulators.
• Academic Research: A key reagent for universities and research institutes exploring the molecular basis of disease and cellular regulation.

Basic Information

Product Name	Hymenialdisine Methanoate
CAS No.	84094-94-0
Molecular Formula	C₁₅H₁₃BrN₄O₃
Molecular Weight	377.19 g/mol
Synonyms	Hymenialdisine Methyl Ether; 2-Bromo-4,5,6,7-tetrahydro-9-methoxy-1H-pyrrolo[2,3-c]azepin-1-one; 9-Methoxyhymenialdisine; GSK-3β Inhibitor XII; CDK Inhibitor (Hymenialdisine derivative); 2-Bromo-9-methoxypyrroloazepinone
EINECS	Contact for details

Quality Control

Our Hymenialdisine Methanoate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material at 2-8°C. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.