Description

Azidothiorphan is a potent and selective inhibitor of the enzyme neprilysin (NEP), also known as neutral endopeptidase. This compound is a critical research tool for studying the role of NEP in the central nervous system and cardiovascular system, particularly in the metabolism of endogenous peptides like enkephalins and natriuretic peptides. It is primarily utilized by pharmaceutical researchers, academic institutions, and R&D laboratories focused on neuropharmacology, pain management, and cardiovascular disease research.

Application

• Neuropharmacology Research: Used to study the role of neprilysin in the degradation of neuropeptides such as enkephalins, substance P, and amyloid-β peptide in the brain.
• Pain Management Studies: Investigated for its potential to enhance endogenous opioid activity by inhibiting enkephalin catabolism, providing insights into novel analgesic pathways.
• Cardiovascular Research: Employed to examine the effects of NEP inhibition on natriuretic peptide levels, blood pressure regulation, and heart failure models.
• Enzyme Inhibition Assays: Serves as a reference standard and selective inhibitor in biochemical assays to characterize NEP activity and screen for new inhibitors.
• Alzheimer's Disease Research: Utilized in studies exploring the link between neprilysin activity and the clearance of amyloid-β, a key peptide in Alzheimer's pathology.
• Preclinical Drug Development: Acts as a key pharmacological tool in animal models to validate NEP as a therapeutic target for various conditions.

Basic Information

Product Name	Azidothiorphan
CAS No.	83960-29-6
Molecular Formula	C15H21N5O3S
Molecular Weight	351.43 g/mol
Synonyms	N-[(R,S)-2-(Azidomethyl)-3-phenyl-1-oxopropyl]-(R,S)-phenylalanine; Azidothiorphan; (R,S)-Azidothiorphan; N-[2-(Azidomethyl)-3-phenylpropionyl]phenylalanine; Neprilysin Inhibitor; NEP Inhibitor; Enkephalinase Inhibitor
EINECS	Contact for details

Quality Control

Our Azidothiorphan is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.