Description

Undecaprenyl Biphosphate-n-Acetylmuramoyl-Pentapeptide is a critical lipid-linked intermediate in the biosynthesis of bacterial peptidoglycan. This compound matters as a key substrate for studying the enzymatic machinery of bacterial cell wall formation, making it an essential tool for antimicrobial research and development. It is primarily needed by pharmaceutical R&D teams, academic biochemistry laboratories, and companies developing novel antibiotics targeting Gram-positive and Gram-negative pathogens.

Application

• Biochemical Research: As a high-purity substrate for in vitro assays studying the Mur enzymes (MraY, MurG) involved in peptidoglycan biosynthesis.
• Antibiotic Discovery: Screening for novel inhibitors that target the essential lipid cycle of bacterial cell wall synthesis, a validated mechanism for antibiotic action.
• Enzyme Kinetics & Mechanism Studies: Used to determine kinetic parameters (Km, Vmax) and elucidate the catalytic mechanisms of translocase and polymerase enzymes.
• Biosynthetic Pathway Analysis: Investigating the complete pathway from UDP-N-acetylmuramic acid to mature peptidoglycan in model organisms like E. coli and S. aureus.
• Development of Diagnostic Tools: Potential use in assays designed to detect bacterial resistance mechanisms related to cell wall precursor synthesis.
• Teaching & Advanced Training: A specialized compound for graduate-level and postdoctoral training in advanced microbiology and medicinal chemistry programs.

Basic Information

Product Name	Undecaprenyl Biphosphate-n-Acetylmuramoyl-Pentapeptide
CAS No.	83919-28-2
Molecular Formula	C95H153N7O26P2
Molecular Weight	~1895.2 g/mol
Synonyms	Undecaprenyl-diphosphoryl-N-acetylmuramoyl-pentapeptide; Lipid I (E. coli type); C55-PP-MurNAc-pentapeptide; Bactoprenyl-PP-MurNAc-L-Ala-D-Glu-m-DAP-D-Ala-D-Ala; Undecaprenyl pyrophosphoryl-MurNAc-pentapeptide; Park's Nucleotide Lipid Intermediate; Peptidoglycan Biosynthesis Intermediate I
EINECS	Contact for details

Quality Control

Our Undecaprenyl Biphosphate-n-Acetylmuramoyl-Pentapeptide is produced and handled under stringent quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization to ensure structural identity and purity. Certificates of Analysis (COA) detailing lot-specific results from NMR, HPLC, and MS analysis are provided to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol/water mixtures, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.