Description

3-Chloro-3-(4-Fluorophenyl)Methacrylaldehyde is a specialized fluorinated and chlorinated aldehyde building block of significant interest in advanced organic synthesis. This compound matters for its unique bifunctional reactivity, offering both an aldehyde group and a halogenated alkene moiety, which enables the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the fluorophenyl group for enhanced biological activity and environmental stability.
• Material Science Monomer: Serves as a functional monomer for creating specialty polymers with tailored properties like thermal stability and specific reactivity.
• Cross-Coupling Reactions: The chloro and aldehyde functionalities make it a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Research: A versatile building block in academic and industrial R&D for exploring new heterocyclic and acyclic compound libraries.

Basic Information

Product Name	3-Chloro-3-(4-Fluorophenyl)Methacrylaldehyde
CAS No.	83783-51-1
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	3-Chloro-3-(4-fluorophenyl)-2-methylpropenal; 2-Propenal, 3-chloro-3-(4-fluorophenyl)-2-methyl-; (E/Z)-3-Chloro-3-(4-fluorophenyl)methacrylaldehyde; 3-Chloro-3-(p-fluorophenyl)-2-methylpropenal; 4-Fluoro-β-chloro-β-methylcinnamaldehyde; 3-Chloro-3-(4-fluorophenyl)-2-methylacrylaldehyde
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-3-(4-Fluorophenyl)Methacrylaldehyde adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation. Keep away from strong bases, oxidizing agents, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.