Description

L-Buthionine-(S,R)-Sulfoximine is a potent and selective inhibitor of γ-glutamylcysteine synthetase, a key enzyme in the glutathione biosynthesis pathway. This compound is a critical research tool for studying oxidative stress, cellular detoxification mechanisms, and the role of glutathione in various physiological and pathological processes. It is essential for researchers and developers in the fields of biochemistry, pharmacology, oncology, and neuroscience, where modulating intracellular glutathione levels is a fundamental experimental approach.

Application

• Biomedical Research: Used as a standard laboratory reagent to deplete intracellular glutathione (GSH) levels in cell culture and animal models, facilitating studies on oxidative stress, apoptosis, and drug resistance.
• Cancer Research: Investigated for its potential to sensitize tumor cells to chemotherapy and radiation therapy by inhibiting glutathione-mediated detoxification pathways.
• Neurodegenerative Disease Studies: Applied in research models to understand the role of oxidative damage in conditions like Parkinson's and Alzheimer's disease.
• Toxicology & Pharmacology: Serves as a tool compound to assess the metabolic pathways and toxicity profiles of drugs and chemicals that interact with the glutathione system.
• Enzyme Inhibition Studies: A specific inhibitor for mechanistic studies of γ-glutamylcysteine synthetase (GCS) enzyme kinetics and regulation.
• Agricultural & Plant Science Research: Used in experimental botany to study plant defense mechanisms and stress responses related to glutathione.

Basic Information

Product Name	L-Buthionine-(S,R)-Sulfoximine
CAS No.	83730-53-4
Molecular Formula	C8H18N2O3S
Molecular Weight	222.30 g/mol
Synonyms	BSO; L-Buthionine Sulfoximine; Buthionine Sulfoximine; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butyric Acid; DL-Buthionine-(S,R)-sulfoximine; γ-Glutamylcysteine Synthetase Inhibitor; NSC 326231; L-BSO
EINECS	Contact for details

Quality Control

Our L-Buthionine-(S,R)-Sulfoximine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.