Description

32-Desmethoxyrapamycin is a potent semi-synthetic derivative of the macrolide immunosuppressant rapamycin (Sirolimus). This compound is of significant interest in biomedical research due to its role as a key intermediate in the synthesis of novel mTOR (mammalian target of rapamycin) pathway inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation immunosuppressive and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of novel rapamycin analogs and mTOR inhibitors.
• Biochemical Research: Used as a reference standard or tool compound in studies investigating the structure-activity relationships (SAR) of the rapamycin family.
• Immunology Studies: Employed in preclinical research to explore mechanisms of immunosuppression and T-cell regulation.
• Oncology Research: Investigated for its potential anti-proliferative effects and utility in developing targeted cancer therapies.
• Process Development: Serves as a key benchmark in scaling up and optimizing synthetic routes for complex macrolide pharmaceuticals.

Basic Information

Item	Details
Product Name	32-Desmethoxyrapamycin
CAS No.	83482-58-0
Molecular Formula	C50H79NO13
Molecular Weight	902.17 g/mol
Synonyms	32-O-Demethoxyrapamycin; 32-Demethoxy Sirolimus; 32-Demethoxyrapamycin; 32-Demethoxysirolimus; 32-Desmethoxy Sirolimus; ABT-578 Intermediate; Zotarolimus Derivative; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
EINECS	Contact for details

Quality Control

Our 32-Desmethoxyrapamycin is manufactured under strict quality control protocols suitable for research and development applications. Each batch is analyzed to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles by HPLC is provided with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the product label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.