Description

D-Ribose-2-13C CAS NO 83379-40-2 is a stable isotope-labeled analog of the essential pentose sugar D-ribose, where the carbon atom at the 2-position is enriched with the 13C isotope. This high-purity labeled compound is critical for advanced research requiring precise metabolic pathway tracing and quantification. It is primarily utilized by researchers and manufacturers in the fields of nuclear magnetic resonance (NMR) spectroscopy, metabolomics, and pharmaceutical development for drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Metabolic Flux Analysis (MFA): As a 13C-labeled tracer for studying central carbon metabolism, glycolysis, and the pentose phosphate pathway in cell cultures and biological systems.
• NMR Spectroscopy Internal Standard: Used as a quantitative internal standard for the accurate measurement of D-ribose and related metabolites in complex biological samples via NMR.
• Pharmaceutical Research: Employed in the synthesis of isotopically labeled nucleosides, nucleotides, and other bioactive molecules for drug discovery and development.
• Biochemical Research: A key substrate for enzymatic studies involving ribokinase, phosphoribosyltransferases, and other enzymes in nucleotide biosynthesis.
• Mass Spectrometry (MS): Serves as a standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) methods to improve accuracy in metabolomic profiling.
• Nutritional Science Studies: Used in research investigating the metabolism and bioavailability of ribose in dietary and supplemental contexts.

Basic Information

Product Name	D-Ribose-2-13C
CAS No.	83379-40-2
Molecular Formula	C413CH10O5
Molecular Weight	151.12 g/mol
Synonyms	D-Ribose-2-13C; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-2-13C; 2-13C-D-Ribose; Ribose-2-13C; D-(-)-Ribose-2-13C; 13C Labeled D-Ribose; Stable Isotope Labeled D-Ribose; 2-13C Ribose
EINECS	Contact for details

Quality Control

Our D-Ribose-2-13C is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity for research applications. Each batch is analyzed to confirm identity, isotopic enrichment, and the absence of critical impurities. Certificates of Analysis (COA) detailing specific lot results for assay, isotopic purity, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Specific Optical Rotation	-20.0° to -23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.