Description

n-Methylfunaltrexamine is a potent and selective opioid receptor antagonist used in advanced pharmacological research. Its primary value lies in its high specificity for the mu-opioid receptor, making it a critical tool for studying receptor function, signal transduction pathways, and the development of novel therapeutic agents. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on neuropharmacology, pain management research, and addiction science. The product is supplied with full analytical documentation to ensure research integrity and reproducibility.

Application

• Pharmacological Research: A key reference standard and tool compound for investigating the binding affinity and functional activity at opioid receptors.
• Neuropharmacology Studies: Used in vitro and in vivo to elucidate the role of mu-opioid receptors in pain signaling, reward pathways, and neurological disorders.
• Drug Discovery & Development: Serves as a critical molecular probe in high-throughput screening (HTS) assays and the preclinical development of new analgesic or anti-addiction medications.
• Biochemical Assay Development: Employed to validate and calibrate receptor binding assays (e.g., radioligand binding) and functional cellular assays.
• Academic Research: Used in university laboratories for graduate and postdoctoral research projects focused on the opioid system.
• Toxicology & Safety Pharmacology: Applied in studies assessing the safety profile and potential side effects of new chemical entities targeting the central nervous system.

Basic Information

Product Name	n-Methylfunaltrexamine
CAS No.	83339-80-4
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	n-Methyl-FNT; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-6-methylenemorphinan-6-one; Methylfunaltrexamine; 6-Methylenenaltrexone derivative; β-Funaltrexamine methyl derivative; Opioid antagonist MFNA; N-Methyl-β-funaltrexamine
EINECS	Contact for details

Quality Control

Every batch of n-Methylfunaltrexamine is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our standard material meets a typical purity specification of ≥98% (by HPLC). Comprehensive analytical testing includes identification by spectroscopic methods (IR, NMR, MS), purity assay by HPLC, and determination of residual solvents. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.