Description

Bryostatin 1 is a potent, naturally occurring macrocyclic lactone isolated from marine bryozoans, with the CAS registry number 83314-01-6. This compound is a highly valuable biochemical tool and investigational agent, primarily recognized for its unique ability to modulate protein kinase C (PKC) activity. It is essential for advanced research in oncology, neuroscience, and immunology, where it is used to study cellular signaling pathways, memory formation, and cancer cell proliferation. Global pharmaceutical R&D teams, academic research institutions, and biotechnology companies specializing in novel therapeutic discovery are the primary end-users of this high-purity compound.

Application

• Biomedical Research: As a critical pharmacological probe for studying Protein Kinase C (PKC) isoforms and their role in signal transduction, cell differentiation, and apoptosis.
• Oncology Studies: Investigation of anti-cancer properties, including potential as an adjuvant therapy to enhance the efficacy of chemotherapeutic agents and in cancer immunotherapy research.
• Neuroscience & Cognitive Research: Exploration of its effects on synaptic plasticity, memory enhancement, and potential therapeutic applications for neurodegenerative diseases like Alzheimer's.
• Immunology & Inflammation: Study of immune cell activation and modulation of inflammatory responses for autoimmune disease research.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and the development of novel PKC-targeting therapeutics.
• Chemical Biology: Used as a precise molecular tool to dissect complex biological pathways and validate drug targets in cellular and animal models.

Basic Information

Item	Details
Product Name	Bryostatin 1
CAS No.	83314-01-6
Molecular Formula	C47H68O17
Molecular Weight	905.03 g/mol
Synonyms	Bryostatin I; Bryostatin-1; NSC 339555; (1S,3S,4S,5R,7S,8S,9R,14S,15R,17S,18S,19S)-19-[(1R)-1-Hydroxyethyl]-4,7,18-trihydroxy-1-[(1E)-3-methoxy-3-oxo-1-propen-1-yl]-14-methyl-9-[(2S,3S)-2-methyl-3-(2-methyl-1-oxopropoxy)oxiran-2-yl]-3,5,8,15,17-pentamethyl-11,20,22-trioxo-2,6-dioxabicyclo[16.3.1]docosa-10,12-dien-21-yl (2E,4E)-2,4-octadienoate
EINECS	Contact for details

Quality Control

Every batch of Bryostatin 1 is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and identity for research use. Our quality control protocol includes comprehensive testing via HPLC, MS, and NMR to confirm structural integrity and potency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay results, and chromatographic data to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.