Description

Tiprinast is a selective phosphodiesterase 4 (PDE4) inhibitor with significant research and development applications. This compound is valued for its role as a key biochemical tool in studying inflammatory pathways and cellular signaling mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in the discovery of novel therapeutics for respiratory and autoimmune conditions.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of new anti-inflammatory drugs.
• Biochemical Assay Development: Used as a selective PDE4 inhibitor to validate assay systems and study enzyme kinetics in vitro.
• Academic & Preclinical Studies: Employed in university and institutional labs to investigate the role of PDE4 in disease models, particularly for asthma, COPD, and psoriasis.
• Drug Discovery Screening: Acts as a positive control or lead compound in high-throughput screening (HTS) campaigns targeting PDE4 for therapeutic intervention.
• Mechanism of Action (MoA) Studies: Utilized to elucidate inflammatory pathways and secondary messenger systems (cAMP) within cellular and animal models.
• Process Chemistry & Scale-Up: Supplied as a building block for process optimization and the synthesis of more complex drug candidates in medicinal chemistry.

Basic Information

Product Name	Tiprinast
CAS No.	83153-39-3
Molecular Formula	C16H17N5O3
Molecular Weight	327.34 g/mol
Synonyms	Tiprinast; 6-(p-Acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinone; 4-[5-Oxo-4,5-dihydro-3H-pyridazin-6-yl]acetanilide; 6-(4-Acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinone; PDE4 Inhibitor Tiprinast; CP-80,633; CP 80633; CP80633
EINECS	Contact for details

Quality Control

Our Tiprinast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.