Description

Cyclopiazonic Acid is a potent and specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase (SERCA) pump, a key enzyme in cellular calcium homeostasis. This high-purity biochemical is essential for researchers investigating calcium signaling pathways, muscle physiology, and cellular stress responses. It is a critical tool compound for pharmaceutical R&D, toxicology studies, and academic research in cell biology and biochemistry.

Application

• Biochemical Research: Used as a selective SERCA pump inhibitor to study intracellular calcium signaling, store-operated calcium entry (SOCE), and ER stress.
• Pharmaceutical Development: Serves as a reference standard and pharmacological tool in drug discovery programs targeting calcium-dependent processes.
• Toxicology & Mycology: Employed in studies of mycotoxin contamination, food safety, and the toxicological profile of fungal metabolites.
• Muscle Physiology Studies: Applied in research on muscle contraction, relaxation, and the role of the SERCA pump in cardiac and skeletal muscle function.
• Cell Biology: Utilized to induce ER calcium depletion and study subsequent cellular responses, including apoptosis and autophagy.
• Neuroscience Research: Aids in exploring the role of calcium in neuronal function, neurotransmitter release, and neurodegenerative disease models.

Basic Information

Product Name	Cyclopiazonic Acid
CAS No.	83136-88-3
Molecular Formula	C₂₀H₂₀N₂O₃
Molecular Weight	336.39 g/mol
Synonyms	CPA; α-Cyclopiazonic Acid; 3,12-Dihydro-6-hydroxy-3-(1H-indol-3-ylmethyl)-8-(1-methylpropyl)-2H,8H-pyrrolo[1,2-a]indolizine-1,7-dione; 2,3,4,4a,5,6-Hexahydro-3-(1H-indol-3-ylmethyl)-8-(1-methylpropyl)-7H-pyrrolo[4,3,2-de]indol-7-one; Mycotoxin CPA; SERCA Inhibitor I
EINECS	Contact for details

Quality Control

Our Cyclopiazonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.