Description

4-Thiaprostaglandin E1 is a synthetic prostaglandin analog where a sulfur atom replaces a methylene group in the carbon chain, offering enhanced metabolic stability for research and development. This structural modification makes it a valuable tool compound for studying prostaglandin receptor activity, signal transduction pathways, and related physiological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular, inflammatory, and metabolic disorder research.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel prostaglandin-based therapeutics.
• Biochemical Research: Used as a ligand to investigate the binding affinity and functional activity of prostaglandin E receptor subtypes (EP1-EP4).
• Cell Signaling Studies: Applied in vitro to modulate cyclic AMP (cAMP) levels and study downstream effects in target cell lines.
• Metabolic Pathway Analysis: A tool for probing the role of prostaglandins in lipid metabolism, inflammation, and vascular tone regulation.
• Analytical Standard: Employed as a high-purity standard for method development and quality control in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	4-Thiaprostaglandin E1
CAS No.	83010-28-0
Molecular Formula	C20H32O5S
Molecular Weight	384.53 g/mol
Synonyms	4-Thia-PGE1; 11α,15α-Dihydroxy-9-oxo-13-thiaprosta-5-cis,10-trans-dien-1-oic Acid; 13-Thiaprostaglandin E1; 4-Thia-PGE1; 13-Thia-PGE1; 9-Oxo-11α,15α-dihydroxy-13-thiaprosta-5-cis,10-trans-dien-1-oic Acid; Thiaprostaglandin E1
EINECS	Contact for details

Quality Control

Our 4-Thiaprostaglandin E1 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, spectroscopic identification (NMR, IR, MS), and determination of critical physical properties. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the primary container under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.