Description

Tazanolast is a potent and selective inhibitor of leukotriene synthesis, specifically targeting 5-lipoxygenase. This compound is of significant interest for its role in modulating inflammatory pathways, making it a valuable research tool and a key intermediate in pharmaceutical development. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors focusing on respiratory and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced anti-inflammatory and anti-allergic drug candidates.
• Biochemical Research: Used as a reference standard and a selective tool compound for studying the 5-lipoxygenase pathway and leukotriene-mediated processes.
• Drug Discovery: Employed in high-throughput screening and target validation for developing new therapeutics targeting asthma, allergic rhinitis, and other inflammatory diseases.
• Academic Research: Utilized in university and institutional labs for investigating the mechanisms of inflammation and evaluating potential new treatment modalities.
• Preclinical Development: Serves as a critical material in formulation studies and pharmacokinetic/pharmacodynamic (PK/PD) modeling during early-stage drug development.

Basic Information

Product Name	Tazanolast
CAS No.	82989-25-1
Molecular Formula	C₁₉H₁₈N₂O₅S
Molecular Weight	386.42 g/mol
Synonyms	4-(3-Chlorophenyl)-1,3-thiazole-5-carboxylic acid; Tazanolastum; Tazanolasto; Tazanolast (USAN); W-2979M; 4-(3-Chlorophenyl)-1,3-thiazole-5-carboxylic acid; 5-Thiazolecarboxylic acid, 4-(3-chlorophenyl)-
EINECS	Contact for details

Quality Control

Our Tazanolast is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.