Description

17β-Estradiol-13C2 CAS NO 82938-05-4 is a stable isotope-labeled analog of the primary female sex hormone, estradiol, where two carbon atoms are replaced with the carbon-13 isotope. This compound is critically important as an internal standard in quantitative mass spectrometry, enabling precise and accurate measurement of endogenous estradiol levels in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and endocrinology research sectors, where reliable analytical data is paramount.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for bioanalytical method development and validation.
• Clinical Research & Diagnostics: Enables accurate measurement of estradiol in serum, plasma, and other biological samples for hormone profiling, fertility studies, and disease research.
• Pharmaceutical Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies of hormone-based therapeutics to track drug metabolism and bioavailability.
• Endocrinology Studies: Facilitates research into hormonal regulation, receptor binding assays, and the metabolic pathways of steroid hormones.
• Veterinary Medicine: Applied in hormone level monitoring and reproductive health studies in animals.
• Forensic Toxicology: Supports the analysis of steroid hormones in forensic investigations and anti-doping control.
• Reference Material Production: Serves as a certified component in the preparation of high-purity reference materials and calibration kits.

Basic Information

Item	Detail
Product Name	17β-Estradiol-13C2
CAS No.	82938-05-4
Molecular Formula	C18H2413C2O2
Molecular Weight	274.39 g/mol (for 13C2 labeled form)
Synonyms	Estradiol-13C2; [13C2]-Estradiol; 13C2-Labeled Estradiol; E2-13C2; (13C2)17β-Estradiol; 1,3,5(10)-Estratrien-3,17β-diol-13C2; Delta4-Estradiol-13C2; Dihydrofolliculin-13C2; Dihydrotheelin-13C2
EINECS	Contact for details

Quality Control

Every batch of 17β-Estradiol-13C2 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications, including isotopic enrichment. Our quality commitment ensures reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure and label
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95% (by 1H NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.