Description

3,4-Difluoropyridine CAS NO 82878-63-5 is a versatile fluorinated heterocyclic building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the pyridine ring, which significantly influences the electronic properties, metabolic stability, and lipophilicity of target molecules. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the difluoropyridine moiety enhances biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for constructing sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Incorporated into the design of organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Fluorine Chemistry Studies: A valuable substrate for investigating nucleophilic aromatic substitution and other fluorination-related reactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D pipelines.

Basic Information

Product Name	3,4-Difluoropyridine
CAS No.	82878-63-5
Molecular Formula	C5H3F2N
Molecular Weight	115.08 g/mol
Synonyms	3,4-Difluoropyridine; Pyridine, 3,4-difluoro-; 3,4-Difluoro-pyridine; 82878-63-5; 3,4-Difluoropyridin; NSC 405124; AI3-52711; LS-183230
EINECS	Contact for details

Quality Control

Our 3,4-Difluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.