Description

2-Chloro-5-Fluorobenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 2-chloro-5-fluorobenzenesulfonyl moiety, a key functional group for modulating the biological activity and physicochemical properties of target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients, specialty chemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides, where the sulfonyl group contributes to efficacy and selectivity.
• Material Science: Employed in the creation of specialty polymers, dyes, and liquid crystals, where it acts as a functionalization agent.
• Chemical Research & Development: Serves as a fundamental reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures for advanced applications.

Basic Information

Item	Details
Product Name	2-Chloro-5-Fluorobenzenesulfonyl Chloride
CAS No.	82875-86-3
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.06 g/mol
Synonyms	2-Chloro-5-fluorobenzenesulfonyl chloride; 1-Chloro-4-fluoro-2-sulfonylchloridobenzene; Benzenesulfonyl chloride, 2-chloro-5-fluoro-; 2-Chloro-5-fluorophenylsulfonyl chloride; 5-Fluoro-2-chlorobenzenesulfonyl chloride; 2-Chloro-5-fluoro-1-benzenesulfonyl chloride; (2-Chloro-5-fluorophenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Fluorobenzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.