Description

Toxin V (Anemonia Sulcata) is a potent neurotoxin derived from the venom of the sea anemone *Anemonia sulcata*. This compound is of significant interest for its high-affinity interaction with voltage-gated sodium channels, making it a critical tool for neurological and pharmacological research. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in neuroscience, ion channel studies, and drug discovery programs.

Application

• Neuroscience Research: As a specific modulator of voltage-gated sodium channels (Nav channels) for studying neuronal excitability and signal transduction.
• Pharmacological Tool: Used in high-throughput screening (HTS) assays to identify and characterize novel analgesic or neuroprotective drug candidates.
• Ion Channel Studies: Essential for electrophysiology experiments to probe the structure, function, and gating mechanisms of specific sodium channel subtypes.
• Toxin & Venom Research: Serves as a reference standard in the comparative analysis of marine toxins and their biological activities.
• Diagnostic Development: Potential use in the development of biochemical assays and biosensors for toxin detection or channelopathy research.
• Biochemical Reagent: Employed in protein interaction studies and the purification of specific channel proteins via affinity chromatography.

Basic Information

Product Name	Toxin V (Anemonia Sulcata)
CAS No.	82869-85-0
Molecular Formula	C164H254N44O53S7 (Representative for ATX II variant)
Molecular Weight	~4700 Da (Contact for details)
Synonyms	Anemonia sulcata Toxin II; ATX II; Sea Anemone Toxin II; Anthopleurin B (AP-B) analog; Sodium Channel Neurotoxin; Anemonia viridis toxin; Neurotoxin V; Voltage-gated Sodium Channel Toxin; CAS 82869-85-0
EINECS	Contact for details

Quality Control

Every batch of Toxin V (Anemonia Sulcata) is produced and analyzed under stringent conditions to ensure identity, purity, and biological activity. Our quality commitment includes comprehensive characterization suitable for research applications. Certificates of Analysis (COA) detailing purity, bioactivity, and analytical methods (HPLC, MS) are provided with each shipment to support your critical work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (Assay)	Activity confirmed via sodium channel assay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers or dilute acetic acid
Protein Content (UV)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.