Description

Leukotriene E-4 Sulfone is a stable sulfone derivative of the cysteinyl leukotriene LTE4, serving as a crucial reference standard and research biochemical. This compound is essential for analytical method development and validation in the study of leukotriene pathways and their physiological roles. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on inflammation, asthma, and allergy research.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and the quantification of leukotrienes in biological samples.
• Biochemical Research: A key tool for investigating the metabolism, stability, and biological activity of cysteinyl leukotrienes in vitro.
• Method Development: Critical for developing and validating sensitive and specific bioanalytical assays in pharmacokinetic and pharmacodynamic studies.
• Inflammation & Immunology Studies: Employed as a stable analog to study the role of leukotrienes in inflammatory diseases such as asthma, allergic rhinitis, and anaphylaxis.
• Quality Control: Serves as an internal standard for the quality assurance of related pharmaceutical compounds and diagnostic kits.

Basic Information

Product Name	Leukotriene E-4 Sulfone
CAS No.	82850-11-1
Molecular Formula	C23H37NO7S2
Molecular Weight	503.67 g/mol
Synonyms	LTE4 Sulfone; 5-Hydroxy-6-(sulfooxy)-7,9,11,14-eicosatetraenoic Acid, 1-(1-Carboxy-4-sulfobutyl)-4-sulfonyl-2,3-didehydro-1H-indol-3-yl Ester; Leukotriene E4 Sulfone; (5S,6R)-7-{(1R,2E,4E,6Z,9Z)-1-[(1-Carboxy-4-sulfobutyl)-4-sulfonyl-2,3-didehydro-1H-indol-3-yl]oxy-2,4,6,9-heptadecatetraen-1-yl}-5-hydroxyoxepan-2-one; N-Acetyl Leukotriene E4 Sulfone
EINECS	Contact for details

Quality Control

Our Leukotriene E-4 Sulfone is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product should be kept in a cool, dry place and allowed to reach room temperature before opening to minimize condensation. Handle with appropriate laboratory safety practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.