Description

5-Bromo-2-Methylthiophene-3-Sulfonyl Chloride is a high-purity, multi-functional organosulfur building block essential for advanced chemical synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and bromo groups—which enable sequential, site-specific functionalization to create complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel thiophene-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the thiophene scaffold contributes to biological activity and environmental stability.
• Material Science Building Block: Employed in the research and development of conductive polymers, organic semiconductors, and advanced ligands for catalysis.
• Custom Chemical Synthesis: Serves as a versatile starting material for contract research organizations (CROs) and CDMOs to produce bespoke compounds for client projects.
• Sulfonamide Library Development: The sulfonyl chloride group is ideal for high-throughput synthesis of diverse sulfonamide libraries for drug discovery screening.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl systems.

Basic Information

Product Name	5-Bromo-2-Methylthiophene-3-Sulfonyl Chloride
CAS No.	82834-48-8
Molecular Formula	C6H4BrClO2S2
Molecular Weight	279.58 g/mol
Synonyms	3-Thiophenesulfonyl chloride, 5-bromo-2-methyl-; 2-Methyl-5-bromothiophene-3-sulfonyl chloride; 5-Bromo-2-methyl-3-thiophenesulfonyl chloride; 5-Bromo-2-methylthiophene-3-sulfonchlorid; 82834-48-8; 5-Br-2-Me-thiophene-3-SO2Cl
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methylthiophene-3-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.