Description

Naloxonazine Dihydrochloride CAS NO 82824-01-9 is a high-purity, selective and irreversible antagonist for the mu-opioid receptor (MOR). This compound is a critical research tool for neuropharmacology, enabling the study of opioid receptor subtypes and their complex signaling pathways. It is essential for scientists in pharmaceutical R&D and academic institutions focused on pain management, addiction research, and central nervous system disorders.

Application

• Neuroscience Research: Used as a selective, irreversible antagonist to block and study mu-opioid receptor (MOR) function in vitro and in vivo.
• Pharmacological Studies: Critical for investigating opioid receptor subtype specificity, binding kinetics, and downstream signaling cascades.
• Pain Management Research: A key tool in developing and characterizing novel analgesic compounds that target the opioid system.
• Addiction and Substance Abuse Research: Employed to study the mechanisms of opioid tolerance, dependence, and withdrawal.
• Biochemical Assay Development: Serves as a reference standard in receptor binding assays and functional cellular tests.
• Academic and Pharmaceutical R&D: Supports basic research and drug discovery programs in universities, research institutes, and biotech companies.

Basic Information

Product Name	Naloxonazine Dihydrochloride
CAS No.	82824-01-9
Molecular Formula	C₂₄H₂₇Cl₂N₅O₄
Molecular Weight	520.41 g/mol
Synonyms	Naloxonazine 2HCl; Naloxonazine HCl; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 1,1'-(1,4-Piperazinediyl)bis[1-(2-hydroxy-3-phenylpropyl)] Dihydrochloride; 1,1'-[1,4-Piperazinediylbis[1-(2-hydroxy-3-phenylpropyl)]]bis[17-(2-propen-1-yl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one] Dihydrochloride; Mu-opioid receptor irreversible antagonist; MOR antagonist naloxonazine
EINECS	Contact for details

Quality Control

Our Naloxonazine Dihydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.