Description

2-n-Propyl-Platelet Activating Factor is a synthetic analog of the potent phospholipid mediator Platelet-Activating Factor (PAF). This compound is a critical research tool for studying PAF receptor signaling pathways and related inflammatory and thrombotic processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular, immunological, and respiratory system pharmacology.

Application

• Biochemical Research: A key reference standard and agonist for investigating PAF receptor (PAFR) biology, signal transduction, and downstream cellular effects.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel PAF receptor antagonists for therapeutic applications.
• Inflammation Studies: Employed in vitro and in vivo models to elucidate mechanisms of acute and chronic inflammation, including neutrophil activation and vascular permeability.
• Cardiovascular Research: Applied in studies of platelet aggregation, thrombosis, and atherosclerosis to understand disease pathology and evaluate potential interventions.
• Respiratory Pharmacology: Used to model bronchoconstriction and airway hyperresponsiveness in asthma and related pulmonary conditions.
• Cell Signaling Pathways: Serves as a precise tool to activate specific G-protein coupled receptor (GPCR) pathways for mechanistic studies in cell biology.

Basic Information

Product Name	2-n-Propyl-Platelet Activating Factor
CAS No.	82637-95-4
Molecular Formula	C26H54NO7P
Molecular Weight	523.68 g/mol
Synonyms	2-n-Propyl-PAF; 1-O-Octadecyl-2-O-propyl-sn-glycero-3-phosphocholine; Propyl-PAF; C18:0-Propyl PAF; PAF C-18:0/Propyl; AGEPC (alkylglycerophosphocholine) analog; Platelet Activating Factor analog; 1-O-Octadecyl-2-propyl-rac-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our 2-n-Propyl-Platelet Activating Factor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for critical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, batch-to-batch consistency, and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to oxidation and moisture. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, ethanol; forms micelles in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.