Description

2-Trifluoroacetamidobenzenesulfonyl Fluoride is a specialized fluorinated sulfonyl fluoride derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its core value lies in its dual reactive sites—the sulfonyl fluoride and the trifluoroacetamide-protected aniline—which enable precise, modular construction of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating sulfonamide-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel sulfonamide drugs, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides with sulfonylurea or sulfonamide moieties.
• Chemical Biology Probe Development: Serves as a precursor for activity-based protein profiling (ABPP) reagents targeting serine hydrolases, leveraging the sulfonyl fluoride warhead.
• Material Science Research: Intermediate for synthesizing functional polymers and advanced materials with specific surface properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a protected aniline and a sulfonyl fluoride handle.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis to create diverse compound libraries for screening.

Basic Information

Product Name	2-Trifluoroacetamidobenzenesulfonyl Fluoride
CAS No.	82422-46-6
Molecular Formula	C8H5F4NO3S
Molecular Weight	271.19 g/mol
Synonyms	2-[(Trifluoroacetyl)amino]benzenesulfonyl Fluoride; N-(2-Sulfonylfluorophenyl)trifluoroacetamide; 2-Aminobenzenesulfonyl Fluoride, N-Trifluoroacetyl-; Benzenesulfonyl fluoride, 2-[(trifluoroacetyl)amino]-; 2-Trifluoroacetamidophenylsulfonyl Fluoride; 2-TFA-Aminobenzenesulfonyl Fluoride; 2-TFABSF
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoroacetamidobenzenesulfonyl Fluoride is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.