Description

Retrothiorphan is a potent and selective inhibitor of the enzyme neprilysin (NEP), playing a crucial role in modulating neuropeptide signaling pathways. This compound is of significant interest in biochemical and pharmacological research for its ability to influence pain perception, inflammation, and cardiovascular function. It serves as a critical research tool for neuroscientists and pharmaceutical developers investigating central nervous system disorders, cardiovascular diseases, and novel analgesic mechanisms.

Application

• Biochemical Research: Used as a selective neprilysin (NEP) inhibitor to study enzyme kinetics, substrate specificity, and the physiological roles of neuropeptides like enkephalins and substance P.
• Neuroscience Studies: A key tool for investigating the modulation of pain pathways, neuroinflammation, and the central effects of neuropeptide degradation in animal models.
• Cardiovascular Research: Employed in studies exploring the role of natriuretic peptides in blood pressure regulation, heart failure, and renal function.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery and development of new analgesic and cardioprotective drugs.
• In Vitro Diagnostics: Used in assay development for screening NEP inhibitor activity and for calibrating enzymatic activity tests.

Basic Information

Product Name	Retrothiorphan
CAS No.	82154-09-4
Molecular Formula	C15H22N2O4S
Molecular Weight	326.41 g/mol
Synonyms	(R)-Retrothiorphan; (R)-N-[(R)-1-Carboxy-2-phenylethyl]alanyl-β-(thien-2-yl)-L-alanine; N-[(1R)-1-Carboxy-2-phenylethyl]-L-alanyl-3-(2-thienyl)-L-alanine; Retro-Thiorphan; Thiorphan Retro-Inverso Isomer; Neprilysin Inhibitor
EINECS	Contact for details

Quality Control

Our Retrothiorphan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is hygroscopic and should be kept in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.