Description

Thiolactomycin is a potent and selective natural product inhibitor of bacterial and plant type II fatty acid synthases (FAS II). This unique mechanism of action makes it a valuable research tool for studying lipid biosynthesis and a promising lead compound for the development of novel antibacterial agents. It is primarily utilized by researchers in pharmaceutical R&D, microbiology, and biochemistry for target validation, mechanism-of-action studies, and antimicrobial discovery programs.

Application

• Antibacterial Research: A key tool compound for investigating novel antibiotic targets, particularly against FAS II-dependent pathogens like Mycobacterium tuberculosis.
• Biochemical Pathway Analysis: Used to selectively inhibit fatty acid synthesis in studies of bacterial and plant metabolic pathways.
• Lead Compound Optimization: Serves as a structural scaffold in medicinal chemistry for designing new classes of antimicrobial agents with reduced resistance potential.
• Microbiology Studies: Employed in laboratory settings to study bacterial growth, membrane composition, and the physiological consequences of disrupted lipid metabolism.
• Plant Science Research: Applied in research on plant-type FAS systems to understand lipid biosynthesis in chloroplasts and its role in plant development.

Basic Information

Product Name	Thiolactomycin
CAS No.	82079-32-1
Molecular Formula	C12H16O3S
Molecular Weight	240.32 g/mol
Synonyms	Thiolactomycin; (4S,5R)-4,5-Dihydro-5-hydroxy-4-(1E)-1-propen-1-yl-2(3H)-thiophenone; TLM; 2(3H)-Thiophenone, 4,5-dihydro-5-hydroxy-4-[(1E)-1-propen-1-yl]-; NSC 354646; Antibiotic 1413; Fatty Acid Synthase II Inhibitor
EINECS	Contact for details

Quality Control

Our Thiolactomycin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.