Description

6-.Beta.-Hydroxyaphidicolin CAS NO 82026-07-1 is a hydroxylated derivative of the natural diterpenoid aphidicolin, a well-known inhibitor of DNA polymerase. This compound is of significant interest in biochemical and pharmaceutical research due to its potential as a more potent or selective tool for studying eukaryotic DNA replication and cell cycle progression. It is primarily utilized by researchers in life sciences, biotechnology, and pharmaceutical development for investigating mechanisms of DNA synthesis and as a lead compound for novel therapeutic agents.

Application

• Biochemical Research: As a specific inhibitor of eukaryotic DNA polymerases alpha and delta for studying DNA replication mechanisms in vitro.
• Cell Biology Studies: Used to synchronize cell cultures by reversibly arresting cells at the G1/S phase boundary of the cell cycle.
• Antiviral Research: Investigation of its potential activity against DNA viruses, such as herpesviruses and poxviruses, by inhibiting viral DNA polymerase.
• Oncology Research: Evaluation of anti-proliferative effects on various cancer cell lines to understand its potential as an anti-cancer agent.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the synthesis and development of novel chemotherapeutic compounds.
• Enzyme Kinetics: A tool compound for detailed kinetic analysis and characterization of DNA polymerase enzyme function and inhibition.

Basic Information

Product Name	6-.Beta.-Hydroxyaphidicolin
CAS No.	82026-07-1
Molecular Formula	C20H32O5
Molecular Weight	352.47 g/mol
Synonyms	6β-Hydroxyaphidicolin; Aphidicolin-6β-ol; (3S,4aR,5R,6R,6aS,10aS,10bR)-6-Hydroxy-5-(hydroxymethyl)-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-2H-benzo[f]chromen-10b-yl acetate; 6β-Hydroxyaphidicolane; NSC 339638
EINECS	Contact for details

Quality Control

Our 6-.Beta.-Hydroxyaphidicolin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.