Description

3-Ketoaphidicolin is a key oxidized derivative of the natural diterpenoid aphidicolin, a potent and specific inhibitor of DNA polymerase α and δ. This compound is valued for its critical role as a biochemical tool in life science research, particularly in the study of eukaryotic DNA replication and cell cycle progression. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors for mechanism-of-action studies, assay development, and as a reference standard.

Application

• Biochemical Research: Used as a selective inhibitor to study the mechanisms of eukaryotic DNA replication and to distinguish between different DNA polymerases.
• Cell Biology Studies: Employed to induce cell cycle arrest at the G1/S phase boundary for investigating cell proliferation, checkpoint controls, and apoptosis.
• Antiviral Research: Serves as a reference compound in the screening and development of antiviral agents, given aphidicolin's known activity against certain viruses.
• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in drug discovery and development pipelines.
• Enzyme Kinetics: A vital tool for characterizing the kinetics and inhibition profiles of DNA polymerases in vitro.

Basic Information

Product Name	3-Ketoaphidicolin
CAS No.	82026-06-0
Molecular Formula	C20H30O4
Molecular Weight	334.45 g/mol
Synonyms	Aphidicolin-3-one; 3-Oxoaphidicolin; 16α-Hydroxy-3-oxoaphidicolan-15-one; (3S,4aR,5R,6S,6aS,10aS,10bR)-6,10b-Dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1,3,4,5,6,6a,9,10,10a,10b-decahydro-2H-benzo[f]chromen-5-yl acetate; Aphidicolin ketone
EINECS	Contact for details

Quality Control

Our 3-Ketoaphidicolin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and research materials to support your critical scientific work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.