Description

10Z-Hymenialdisine is a marine-derived alkaloid and a potent, selective inhibitor of several key protein kinases, including cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3β (GSK-3β). This compound matters as a critical research tool for studying cell cycle regulation, signal transduction pathways, and neurodegenerative diseases. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, neurology, and drug discovery.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of specific kinases (e.g., CDK1, CDK2, CDK5, GSK-3β) in cellular processes.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of novel therapeutics for cancer and Alzheimer's disease.
• Cell Biology Studies: Employed to investigate cell cycle progression, apoptosis, and neuronal function in various in vitro models.
• Signal Transduction Pathway Analysis: A key reagent for dissecting the Wnt/β-catenin and other kinase-mediated signaling cascades.
• Neuroscience Research: Utilized in studies exploring tau protein phosphorylation and its implications in neurodegenerative disorders.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	10Z-Hymenialdisine
CAS No.	82005-12-7
Molecular Formula	C₁₁H₁₀BrN₅O
Molecular Weight	308.13 g/mol
Synonyms	Hymenialdisine; (10Z)-Hymenialdisine; 2-Bromo-9H-pyrrolo[2,3-c]azepin-8(7H)-one, 4,5,6,9-tetrahydro-7-(1H-imidazol-5-ylmethyl)-, (10Z)-; 7-(1H-Imidazol-4-ylmethyl)-4,5,6,9-tetrahydro-2-bromo-9H-pyrrolo[2,3-c]azepin-8(7H)-one; Kinase inhibitor Hymenialdisine; GSK-3β Inhibitor IX; CDK Inhibitor (Hymenialdisine)
EINECS	Contact for details

Quality Control

Our 10Z-Hymenialdisine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.