Description

4-Oxo-3,4-Dihydroquinazoline-6-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the quinazolinone pharmacophore, a privileged scaffold in medicinal chemistry, into target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small molecule drugs targeting cancer, inflammation, and central nervous system disorders.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with the quinazolinone core structure.
• Chemical Biology Probe Development: Used to create activity-based probes for studying enzyme function and target engagement in drug discovery.
• Material Science Research: Intermediate for synthesizing functional organic molecules with potential applications in organic electronics or as ligands in catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for the production of bespoke compounds and libraries.

Basic Information

Product Name	4-Oxo-3,4-Dihydroquinazoline-6-Sulfonyl Chloride
CAS No.	81870-98-6
Molecular Formula	C8H5ClN2O3S
Molecular Weight	244.66 g/mol
Synonyms	6-Quinazolinesulfonyl chloride, 3,4-dihydro-4-oxo-; Quinazoline-6-sulfonyl chloride, 3,4-dihydro-4-oxo-; 4-Oxo-3,4-dihydroquinazoline-6-sulfonyl chloride; 3,4-Dihydro-4-oxoquinazoline-6-sulfonyl chloride; 81870-98-6; 4-Oxo-1,4-dihydroquinazoline-6-sulfonyl chloride; 6-(Chlorosulfonyl)-4(3H)-quinazolinone
EINECS	Contact for details

Quality Control

Our 4-Oxo-3,4-Dihydroquinazoline-6-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.