Description

Treprostinil is a synthetic analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is of critical importance in the pharmaceutical industry for the development of treatments targeting pulmonary arterial hypertension (PAH). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the synthesis of advanced cardiovascular and pulmonary therapeutics, as well as in biochemical research exploring prostaglandin pathways.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of medications for the treatment of pulmonary arterial hypertension (PAH).
• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in the discovery and development of new vasodilatory and anti-thrombotic drugs.
• Biochemical Studies: Used in laboratory research to study the role of prostacyclin receptors in vascular biology, smooth muscle relaxation, and platelet function.
• Controlled-Release Drug Delivery Systems: Investigated for incorporation into advanced delivery platforms, such as subcutaneous pumps or transdermal patches, to provide sustained therapeutic effects.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods to ensure product identity and purity.

Basic Information

Product Name	Treprostinil
CAS No.	81846-19-7
Molecular Formula	C23H34O5
Molecular Weight	390.51 g/mol
Synonyms	UT-15; UNII-4A0Z64RQ5I; 15-Aminomethyldihydroprostaglandin I2; (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid; Remodulin (brand name); Tyvaso (brand name); Orenitram (brand name); Prostacyclin analog
EINECS	Contact for details

Quality Control

Our Treprostinil is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical intermediates and APIs. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications developed in alignment with ICH Q3 and current Good Manufacturing Practice (cGMP) principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.