Description

1A,1B-Dihomo-Thromboxane B2 is a stable analog of thromboxane, a key bioactive lipid mediator involved in platelet aggregation and vasoconstriction. This compound is a critical reference standard and research tool for studying thromboxane receptor pharmacology and signaling pathways in cardiovascular and inflammatory diseases. It is essential for pharmaceutical R&D, analytical laboratories, and academic institutions focused on eicosanoid biology and drug discovery.

Application

• Pharmaceutical Research & Development: Used as a high-purity reference standard in the discovery and development of novel anti-thrombotic and anti-inflammatory agents.
• Biochemical Assays: Serves as a critical agonist/ligand in in vitro assays to study thromboxane receptor (TP receptor) activity, selectivity, and downstream signaling.
• Analytical Chemistry: Employed as a certified standard for the calibration and validation of analytical methods (e.g., LC-MS, HPLC) in bioanalytical and metabolomics studies.
• Academic Research: A vital tool for investigating the role of thromboxane analogs in physiological and pathophysiological processes related to hemostasis, atherosclerosis, and asthma.
• Metabolite Identification: Used in studies to identify and quantify thromboxane pathway metabolites in complex biological samples.

Basic Information

Product Name	1A,1B-Dihomo-Thromboxane B2
CAS No.	81827-76-1
Molecular Formula	C23H38O6
Molecular Weight	410.55 g/mol
Synonyms	1A,1B-Dihomo-TXB2; Dihomothromboxane B2; (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxythromboxa-5,13-dien-1-oic Acid (extended analog); Thromboxane B2 Dihomo Analog; TXB2 Dihomo Analog; 1A,1B-Dihomo-11-dehydro-thromboxane B2 (related); Carboxythromboxane B2 Analog
EINECS	Contact for details

Quality Control

Our 1A,1B-Dihomo-Thromboxane B2 is manufactured under strict quality control protocols to ensure the highest standards of purity and consistency required for research and development. Each batch is characterized using advanced analytical techniques, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.