Description

Mercapto-β-Cyclodextrin is a chemically modified derivative of β-cyclodextrin featuring thiol (-SH) functional groups, which impart unique reactivity and binding capabilities. This modification is critical for creating advanced host-guest complexes with enhanced affinity for metal ions and organic molecules, enabling precise molecular encapsulation and delivery. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors seeking to develop novel drug delivery systems, biosensors, and separation media.

Application

• Pharmaceutical Drug Delivery: Serves as a functional excipient for creating targeted and sustained-release formulations by forming inclusion complexes with active pharmaceutical ingredients (APIs).
• Biosensor & Diagnostic Development: Utilized to immobilize enzymes, antibodies, or other biorecognition elements onto electrode surfaces via thiol-gold chemistry for enhanced sensor stability and sensitivity.
• Chiral Separation & Analysis: Acts as a chiral selector in capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) for the resolution of enantiomers in pharmaceutical and chemical analysis.
• Catalyst & Ligand Support: The thiol groups can coordinate with metal ions (e.g., gold, palladium) to create heterogeneous catalysts or scavengers for chemical synthesis and purification processes.
• Environmental Remediation: Employed in functionalized materials for the selective capture and removal of heavy metal ions (e.g., mercury, lead) from wastewater.
• Cosmetic & Personal Care: Used to stabilize and control the release of fragrances, vitamins, or active compounds in topical formulations.

Basic Information

Product Name	Mercapto-β-Cyclodextrin
CAS No.	81644-55-5
Molecular Formula	C42H70O35S7 (Representative for heptakis(6-deoxy-6-mercapto)-β-cyclodextrin)
Molecular Weight	Approx. 1439.5 g/mol (for heptakis-substituted form)
Synonyms	6-Mercapto-β-cyclodextrin; 6-Deoxy-6-mercapto-β-cyclodextrin; Heptakis(6-deoxy-6-mercapto)-β-cyclodextrin; Thiolated β-cyclodextrin; β-CD-SH; SH-β-CD; Cyclodextrin, mercapto deriv.; 6-SH-β-CD
EINECS	Contact for details

Quality Control

Our Mercapto-β-Cyclodextrin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Specifications are aligned with research and pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) documenting assay (by HPLC), degree of substitution (DS), residual solvent content, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Degree of Substitution (DS)	Typically 5.0 - 7.0
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.