Description

Neocarzinostatin Chromophore is the active, non-protein chromophore component of the enediyne antitumor antibiotic neocarzinostatin. This compound is of significant interest for its potent DNA-cleaving activity and its role as a model for studying enediyne-based therapeutics. It is primarily utilized by researchers in pharmaceutical development, oncology research, and biochemistry for investigating novel cancer treatment mechanisms and drug delivery systems.

Application

• Anticancer Research: Serves as a critical reference standard and active agent in studies exploring the mechanism of action of enediyne antibiotics.
• Biochemical Tool: Used to induce site-specific DNA strand scission in molecular biology and genetic research applications.
• Pharmaceutical Development: Acts as a lead compound or model for the design and synthesis of novel targeted chemotherapeutic agents.
• Mechanistic Studies: Employed in academic and industrial laboratories to study apoptosis, cell cycle arrest, and DNA damage repair pathways.
• Analytical Standard: Essential for the quality control and HPLC/LC-MS analysis of neocarzinostatin and related fermentation products.

Basic Information

Product Name	Neocarzinostatin Chromophore
CAS No.	81604-85-5
Molecular Formula	C₃₅H₄₈N₄O₁₂
Molecular Weight	716.78 g/mol
Synonyms	NCS Chromophore; Neocarzinostatin Chromophore A; NCS-C; (1S,2R,3S,4S,5S,6R,7S,8S,9R,10S,11S,12R,13S,14R,15S,16S,17S,18R,19S,20S,21S,22R,23S,24S,25S,26R,27S,28S,29R,30S,31S,32R,33S,34R,35S)-35-[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34-tetratriacontahydroxy-1-methyl-16,19,22,25,28,31-hexaoxa-34-azaoctacyclo[29.2.2.2³,⁶.2⁸,¹¹.2¹³,¹⁶.2¹⁸,²¹.2²³,²⁶.2²⁹,³²]pentatriacontane-15,18,21,24,27,30-hexone
EINECS	Contact for details

Quality Control

Our Neocarzinostatin Chromophore is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are accompanied by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and related substance profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.