Description

5-Bromo-4-Methyl-2-Thiophenesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. This compound is essential for introducing the 5-bromo-4-methyl-2-thiophenesulfonyl moiety, enabling the creation of complex molecules with tailored properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications ranging from drug discovery to the development of functional polymers and electronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of conductive polymers, organic semiconductors, and advanced polymeric materials.
• Chemical Biology & Proteomics: Employed as a reactive handle for bioconjugation and the development of chemical probes to study biological systems.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized dyes and pigments containing heterocyclic structures.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs developing proprietary compounds for clients.

Basic Information

Product Name	5-Bromo-4-Methyl-2-Thiophenesulfonyl Chloride
CAS No.	81597-51-5
Molecular Formula	C5H4BrClO2S2
Molecular Weight	275.57 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 5-bromo-4-methyl-; 5-Bromo-4-methylthiophene-2-sulfonyl chloride; 4-Methyl-5-bromothiophene-2-sulfonyl chloride; 5-Bromo-4-methyl-2-thienylsulfonyl chloride; 81597-51-5; 5-Br-4-Me-2-thiophenesulfonyl Cl
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-4-Methyl-2-Thiophenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.