Description

1-Fluoro-3-(2,2,2-Trifluoroethyl)Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a trifluoroethyl side chain, makes it a valuable precursor for introducing lipophilic and electron-withdrawing properties into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated motifs that can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine and trifluoroethyl groups can improve biological activity and environmental persistence profiles.
• Liquid Crystal & Electronic Materials: Serves as a building block for fluorinated liquid crystals and organic semiconductors, contributing to desired dielectric and optical properties.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to develop specialty polymers with enhanced chemical resistance, thermal stability, and unique surface characteristics.
• Organic Synthesis & Catalysis Research: Employed in methodological studies, such as cross-coupling reactions and C-H functionalization, to explore new synthetic pathways.
• Fluorine Chemistry Reagent: Acts as a standard or reference compound in analytical laboratories and for studying structure-activity relationships (SAR) in fluorinated systems.

Basic Information

Product Name	1-Fluoro-3-(2,2,2-Trifluoroethyl)Benzene
CAS No.	81577-08-4
Molecular Formula	C8H6F4
Molecular Weight	178.13 g/mol
Synonyms	3-(2,2,2-Trifluoroethyl)fluorobenzene; m-(Trifluoroethyl)fluorobenzene; 1-Fluoro-3-(trifluoroethyl)benzene; 3-Fluoro-α,α,α-trifluoroethylbenzene; (3-Fluorophenyl)trifluoroethane; Benzene, 1-fluoro-3-(2,2,2-trifluoroethyl)-; 3-(Trifluoroethyl)fluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 1-Fluoro-3-(2,2,2-Trifluoroethyl)Benzene is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by GC, HPLC, and NMR is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed and stored upright away from heat sources and open flames.

Specification

Item	Specification
Appearance	Clear Colorless to Pale Yellow Liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Report on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.