Description

Vincaleukoblastine, O(Sup 4)-Deacetyl-3-De(Methoxycarbonyl)-3-(((2-Eth Oxy-1-(1H-Indol-3-Ylmethyl)-2-Oxoethyl)Amino)Carbonyl)-, (3(R))- is a complex semi-synthetic derivative of the natural alkaloid vinblastine, representing a key intermediate in advanced pharmaceutical research. This compound is of critical importance for the development of novel therapeutic agents, particularly in oncology, due to its role as a precursor for more potent and targeted anti-mitotic drugs. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on next-generation cancer treatments and chemical biology studies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel vinca alkaloid analogs and antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active material in preclinical studies to investigate mechanisms of tubulin binding, mitotic inhibition, and apoptosis induction.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and reduced toxicity profiles compared to parent compounds.
• Bioconjugation Studies: Utilized in the development of drug-linker systems for the creation of advanced targeted therapeutics, leveraging its modifiable functional groups.
• Process Chemistry Development: Acts as a key intermediate for scaling up the production of experimental anti-cancer candidates under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Supports fundamental biochemical and pharmacological research into cell cycle regulation and the development of drug resistance mechanisms.

Basic Information

Product Name	Vincaleukoblastine, O(Sup 4)-Deacetyl-3-De(Methoxycarbonyl)-3-(((2-Eth Oxy-1-(1H-Indol-3-Ylmethyl)-2-Oxoethyl)Amino)Carbonyl)-, (3(R))-
CAS No.	81571-34-8
Molecular Formula	C48H58N4O9
Molecular Weight	834.99 g/mol
Synonyms	Deacetylvinblastine hydrazide; 4-Deacetyl-3-de(methoxycarbonyl)-3-[[[2-ethoxy-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino]carbonyl]vincaleukoblastine; Vinblastine derivative, 4-deacetyl-3-de(methoxycarbonyl)-3-(((2-ethoxy-1-(indol-3-ylmethyl)-2-oxoethyl)amino)carbonyl)-; 4-Deacetyl-3-de(methoxycarbonyl)-vincaleukoblastine-3-carboxylic acid N-(2-ethoxy-1-(indol-3-ylmethyl)-2-oxoethyl)amide; (3R)-4-Deacetyl-3-de(methoxycarbonyl)-3-({[2-ethoxy-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino}carbonyl)vincaleukoblastine
EINECS	Contact for details

Quality Control

Our Vincaleukoblastine derivative is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.