Description

Concanamycin C CAS NO 81552-34-3 is a potent and specific macrolide antibiotic belonging to the concanamycin family, known for its role as a highly effective V-ATPase inhibitor. This compound is a critical research tool for studying intracellular pH regulation, vesicular trafficking, and autophagy processes in cell biology. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on cancer research, neurobiology, and lysosomal function.

Application

• Biochemical Research: As a selective inhibitor of vacuolar-type H+-ATPase (V-ATPase) to study organelle acidification and intracellular pH dynamics.
• Cancer Research: Investigation of autophagy pathways and the role of V-ATPase in tumor cell survival, metastasis, and drug resistance.
• Neuroscience Studies: Research into neurotransmitter uptake and storage in synaptic vesicles, which is dependent on V-ATPase activity.
• Microbiology & Antibiotic Studies: Used in studies of macrolide antibiotic mechanisms and structure-activity relationships.
• Pharmaceutical Development: Serves as a reference standard and a lead compound for developing novel therapeutics targeting V-ATPase in various diseases.
• Cell Biology: Tool compound for probing endocytic and lysosomal pathways, membrane fusion events, and protein degradation.

Basic Information

Product Name	Concanamycin C
CAS No.	81552-34-3
Molecular Formula	C46H75NO14
Molecular Weight	866.1 g/mol
Synonyms	Concanamycin C; Antibiotic X 4357B; Concanolide C; NSC 365812; 28,29-Didehydrorifamycin S; (3E,5E,7E,9E,11E,13E,15E)-17-[(2R,3S,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-4,6,8,10,12,14,16-heptamethyl-18-oxooctadeca-3,5,7,9,11,13,15-heptaen-2-yl 3,5-dihydroxy-2,4-dimethylbenzoate
EINECS	Contact for details

Quality Control

Our Concanamycin C is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is light-sensitive and should be handled under appropriate conditions to maintain potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.