Description

Concanamycin B CAS NO 81552-33-2 is a potent and specific macrolide antibiotic belonging to the concanamycin family, known for its role as a highly effective vacuolar-type H+-ATPase (V-ATPase) inhibitor. This compound is critical for researchers investigating intracellular pH regulation, vesicular trafficking, and autophagy processes in cell biology. It is an essential biochemical tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on cancer research, neurobiology, and lysosomal storage disorders.

Application

• Biochemical Research: Used as a selective V-ATPase inhibitor to study intracellular acidification, organelle function, and ion transport mechanisms.
• Cancer Research: Investigated for its potential to induce apoptosis and inhibit metastasis by disrupting pH homeostasis in tumor cells.
• Neurobiology Studies: Applied in research on neurotransmitter release and synaptic vesicle recycling, where V-ATPase activity is crucial.
• Autophagy & Lysosomal Function: A key reagent for modulating autophagic flux and studying lysosome-related diseases.
• Antifungal & Antibiotic Studies: Serves as a reference standard in microbiological research due to its inherent antibiotic properties.
• Pharmaceutical Development: Utilized in high-throughput screening (HTS) and target validation for drug discovery programs targeting V-ATPase.

Basic Information

Product Name	Concanamycin B
CAS No.	81552-33-2
Molecular Formula	C46H75NO14
Molecular Weight	866.1 g/mol
Synonyms	Concanamycin B; Antibiotic X 4357 B; Folimycin; V-ATPase inhibitor Concanamycin B; NSC 365812; Concanolide B; 28,29-Didehydropolynactin
EINECS	Contact for details

Quality Control

Our Concanamycin B is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and biological activity assays. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Biological Activity	V-ATPase Inhibition (IC50) provided on COA
Solubility	Soluble in DMSO, ethanol, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.