Description

Pepstatin Ketone Analog is a potent and specific synthetic inhibitor of aspartic proteases, designed as a stable, non-hydrolyzable analog of the natural inhibitor pepstatin A. This compound is critical for biochemical research and pharmaceutical development, offering enhanced stability and resistance to enzymatic degradation. It is primarily utilized by researchers in life sciences, medicinal chemistry, and drug discovery for studying protease mechanisms, high-throughput screening, and developing novel therapeutic agents.

Application

• Biochemical Research: A key tool for the specific inhibition of aspartic proteases (e.g., renin, cathepsin D, HIV-1 protease) in enzymatic assays and mechanistic studies.
• Drug Discovery & Medicinal Chemistry: Serves as a lead compound or reference standard in the design and screening of new protease-targeted pharmaceuticals.
• Proteomics & Cell Biology: Used to elucidate the biological roles of specific aspartic proteases in cellular pathways, signal transduction, and disease models.
• High-Throughput Screening (HTS): Employed as a control or validation compound in assay development for identifying new protease inhibitors.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of protease-inhibitor complexes.
• Diagnostic Development: Potential use in the development of diagnostic kits and assays for diseases linked to aspartic protease activity.

Basic Information

Product Name	Pepstatin Ketone Analog
CAS No.	81485-13-4
Molecular Formula	C₃₄H₆₃N₅O₉
Molecular Weight	685.89 g/mol
Synonyms	Pepstatin A Ketone Analog; Isovaleryl-Val-Val-Sta-Ala-Sta Ketone; (3S,4S)-4-Amino-3-hydroxy-6-methylheptanoyl-L-valyl-N-[(1S,2S)-1-benzyl-2-hydroxy-3-[(3-methyl-1-oxobutyl)amino]-3-oxopropyl]-L-valinamide; Statine Ketone Analog; Aspartic Protease Inhibitor Ketone; HIV Protease Inhibitor Ketone Analog; Renin Inhibitor Analog
EINECS	Contact for details

Quality Control

Our Pepstatin Ketone Analog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.