Description

n-Demethylmenogaril is a key pharmaceutical intermediate and reference standard of significant interest in oncology research and development. This compound matters for its role in the synthesis and analytical characterization of anthracycline-based chemotherapeutic agents. Pharmaceutical manufacturers and research institutions require high-purity n-Demethylmenogaril CAS NO 81445-91-2 for drug development, quality control, and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel anthracycline chemotherapeutic agents and their analogs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism of menogaril and related compounds.
• Biochemical Research: Serves as a tool compound for investigating mechanisms of action, particularly topoisomerase II inhibition and DNA intercalation.
• Impurity Standard: Essential for identifying and quantifying related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Academic & Contract Research: Utilized in university labs and CROs (Contract Research Organizations) for preclinical cancer research and drug discovery programs.

Basic Information

Product Name	n-Demethylmenogaril
CAS No.	81445-91-2
Molecular Formula	C30H33NO11
Molecular Weight	583.58 g/mol
Synonyms	7-O-Methylnogalarol; 7-OMEN; Demethylmenogaril; 7-O-Methylnogalareol; 4-Demethoxy-7-O-methylnogalarol; NSC 354646; 7-O-Methyl-4-demethoxynogalarol; Anthracycline derivative 7-OMEN
EINECS	Contact for details

Quality Control

Our n-Demethylmenogaril is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting all test results and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.