Description

5,6-Epoxy-13-Cis Retinoic Acid is a synthetic derivative of retinoic acid, a compound of significant interest in biochemical research and pharmaceutical development. This epoxidized analog is valued for its specific biological activity and utility as a key intermediate in synthesizing more complex retinoid compounds. It is primarily sought by research institutions and pharmaceutical companies engaged in the study of cell differentiation, dermatology, and oncology. The compound's defined structure makes it a crucial tool for investigating retinoid receptor pathways and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel retinoid-based drugs targeting various skin conditions and cancers.
• Biochemical Research: Used as a reference standard and active compound in studies of cellular differentiation, proliferation, and apoptosis mediated by retinoid receptors (RARs/RXRs).
• Dermatology Research: Investigated for its potential effects on skin cell regulation and as a precursor to compounds for treating acne, psoriasis, and photoaging.
• Oncology Research: Employed in preclinical studies to explore anti-proliferative and pro-differentiation effects on various cancer cell lines.
• Metabolic Pathway Studies: Utilized to map the metabolism and biological activity of retinoid analogs in vitro and in vivo.
• Reference Standard: Provides a high-purity standard for analytical methods (HPLC, LC-MS) in quality control and pharmacokinetic studies.

Basic Information

Product Name	5,6-Epoxy-13-Cis Retinoic Acid
CAS No.	81444-57-7
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.44 g/mol
Synonyms	13-cis-5,6-Epoxyretinoic Acid; (13Z)-5,6-Epoxyretinoic Acid; 5,6-Epoxy-13-cis-Retinoate; 5,6-Epoxyisotretinoic Acid; Ro 22-6595; Retinoic Acid, 5,6-epoxy-13-cis-; 5,6-Epoxy-13-cis-Vitamin A Acid
EINECS	Contact for details

Quality Control

Our 5,6-Epoxy-13-Cis Retinoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, keep desiccated at -20°C. The container should be clearly labeled and handled in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.