Description

6-Hydroxynorketamine is a significant metabolite of ketamine, a compound of high interest in modern neuroscience and pharmaceutical research. Its primary value lies in its role as a key analytical reference standard and a crucial intermediate for investigating the metabolic pathways and pharmacological activity of ketamine and its derivatives. This product is essential for research and development laboratories in the pharmaceutical, forensic, and academic sectors focused on neuropharmacology, analytical method development, and metabolite profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of ketamine metabolites in biological matrices during drug development and clinical studies.
• Metabolite Research: Critical for studying the pharmacokinetics, metabolic pathways, and potential biological activity of ketamine and related arylcyclohexylamines.
• Forensic Analysis: Serves as a high-purity standard for the accurate identification and quantification of 6-Hydroxynorketamine in forensic toxicology laboratories.
• Biochemical Research: Employed in in-vitro and in-vivo studies to understand the mechanisms of action and the role of specific metabolites in the effects of dissociative anesthetics.
• Method Development & Validation: Used by analytical chemists to develop, optimize, and validate chromatographic methods (HPLC, LC-MS/MS) for metabolite detection.
• Chemical Synthesis Intermediate: Acts as a key building block or precursor in the synthesis of novel chemical entities for research purposes.

Basic Information

Product Name	6-Hydroxynorketamine
CAS No.	81395-70-2
Molecular Formula	C13H16ClNO2
Molecular Weight	253.73 g/mol
Synonyms	6-Hydroxy norketamine; 2-(2-Chlorophenyl)-2-(methylamino)-6-hydroxycyclohexanone; 6-HNK; (2R,6R)-6-Hydroxynorketamine; (2S,6S)-6-Hydroxynorketamine; Nor-6-Hydroxyketamine; 6-Hydroxy-N-desmethylketamine
EINECS	Contact for details

Quality Control

Our 6-Hydroxynorketamine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is analyzed using advanced techniques including HPLC, GC-MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.