Description

n-α-T-Boc-Deacetylleupeptin CAS NO 81344-47-0 is a protected peptide derivative, specifically a modified form of the natural protease inhibitor leupeptin. This compound is a critical intermediate and research tool in organic synthesis and biochemical studies, offering controlled reactivity for building complex molecular architectures. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and peptide chemistry for investigating enzyme mechanisms and synthesizing novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of more complex protease inhibitors and therapeutic peptides.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays to study serine and cysteine protease activity.
• Proteomics: Employed in laboratory settings to inhibit specific proteases during protein extraction and purification protocols.
• Peptide Synthesis: Serves as a protected precursor for the solid-phase or solution-phase synthesis of leupeptin analogs.
• Cell Biology Studies: Applied in research to prevent protein degradation in cell lysates and tissue samples.
• Academic & Industrial R&D: Fundamental reagent for investigating structure-activity relationships (SAR) in medicinal chemistry projects.

Basic Information

Product Name	n-α-T-Boc-Deacetylleupeptin
CAS No.	81344-47-0
Molecular Formula	C₂₀H₃₇N₅O₆
Molecular Weight	443.54 g/mol
Synonyms	Boc-Leu-Leu-Arg-al; N-[(tert-Butoxy)carbonyl]-L-leucyl-N-[(1S)-1-[[(1S)-1-[[(4S)-4-amino-1-[(diaminomethylidene)amino]butyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-L-leucinamide; tert-Butyl N-[(2S)-1-[[(2S)-1-[[(4S)-4-amino-1-(diaminomethylideneamino)butyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate; Boc-Leu-Leu-Arg-H; Deacetylleupeptin, N-α-t-Boc-
EINECS	Contact for details

Quality Control

Our n-α-T-Boc-Deacetylleupeptin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research and synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications. We support compliance with various research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.