Description

1-Allyl-3-Isobutyl-8-Methylxanthine is a high-purity, synthetic xanthine derivative with significant pharmacological research interest. This compound is valued for its role as a potent and selective adenosine receptor antagonist, making it a critical intermediate and reference standard in drug discovery and development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing novel therapeutics targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Research & Development: Serves as a key chemical entity and reference standard in the study of adenosine receptor (A1, A2A, A2B, A3) pharmacology.
• Drug Discovery Intermediate: Used as a critical building block in the synthesis of novel xanthine-based drug candidates for potential therapeutic applications.
• Biochemical Assay Development: Employed as a selective antagonist to validate and characterize adenosine receptor binding assays and functional cellular tests.
• Academic & Clinical Research: Supports fundamental research into the role of adenosine signaling in conditions like inflammation, ischemia, and sleep regulation.
• Fine Chemical Synthesis: Acts as a specialized intermediate for the custom synthesis of more complex, targeted molecular structures.
• Reference Material Production: Supplied as a certified reference material (CRM) for quality control and analytical method validation in regulatory submissions.

Basic Information

Product Name	1-Allyl-3-Isobutyl-8-Methylxanthine
CAS No.	81250-17-1
Molecular Formula	C14H20N4O2
Molecular Weight	276.34 g/mol
Synonyms	1-Allyl-3-isobutyl-8-methyl-3,7-dihydro-1H-purine-2,6-dione; 1-Allyl-3-isobutyl-8-methylxanthine; 8-Methyl-1-allyl-3-isobutylxanthine; A-80240; Isobutyl-methylxanthine derivative; Adenosine receptor antagonist A-80240; 3-Isobutyl-1-allyl-8-methylxanthine
EINECS	Contact for details

Quality Control

Our 1-Allyl-3-Isobutyl-8-Methylxanthine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and impurity profiles. We adhere to cGMP guidelines where applicable for the production of this non-compendial material, ensuring traceability and reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.